การศึกษาหน้าที่ของ Memory B cell subsets ในโรคมาลาเรียเพื่อนำไปสู่การพัฒนากลยุทธ์ในการพัฒนาวัคซีนโดยการกระตุ้นให้ร่างกายสร้างแอนติบอดีชนิด Neutralizing antibodies
Understanding function of different subsets of memory B cells in malaria: Approach to developing vaccination strategy in inducing protective neutralizing antibodies
In this study, the promising blood stage vaccine candidate of P. vivax malaria and the common polymorphic strain among Thai vivax isolates (DBL-TH antigens) will be carried out as the antigen for demonstrating function of different subsets of malaria-specific MBCs in inducing long-term response and producing neutralizing antibody. Therefore, in this proposal, we plan to address the function of memory B cell subsets in three specific aims:
1. To explore the development and persistence of the different subsets of MBCs in malaria patients.
2. To investigate the ability of a particular memory B cell subsets in producing long-term neutralizing antibody responses.
3. To analyze the repertoire of neutralizing antibodies derived from the certain MBC subsets for identifying target epitopes of these antibodies in vaccine development.
