การค้นหาผลิตภัณฑ์ธรรมชาติที่มีคุณสมบัติในการต้านมะเร็งโดยการใช้ Saccharomyces cerevisiae chemical genetic synthetic lethality screen
Interrogation of natural products using a Saccharomyces cerevisiae chemical genetic synthetic lethality screen to identify anticancer agents
หัวหน้าโครงการ
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ลาเรน เจนเซน
ทีมวิจัย
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ลาเรน เจนเซน
หัวหน้าโครงการ
วันที่เริ่มโครงการ
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16 มิ.ย. 2557
วัตถุประสงค์
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The goals of this project are to identify and characterize natural products with anticancer activity present in the flora of Thailand using a S. cerevisiae chemical genetics synthetic lethality screen. Anticancer activity of natural products will be evaluated using S. cerevisiae strains defective in DNA damage repair and cell cycle checkpoints to mimic common mutations found in cancer cells. Our research team has extensive experience in the use of model systems to investigate basic biological processes that will allow for screening of plant extracts and ultimately isolated compounds with the assistance of our collaborators from the Chulalongkorn University Drug and Health Products Innovation Center at the Faculty of Pharmaceutical Sciences. The aims of this study are (i) identify bioactive natural products from Thai medicinal plants which exhibit anticancer activities; (ii) characterize the identified natural products and deduce the molecular targets; and (iii) determine anticancer activity of natural products against human cancer cell lines to validate results from the yeast model system.
