1 To investigate the protective mechanisms of primary human keratinocytes (HeKn) against UVB-induced apoptosis and DNA damage in primary human melanocytes (HeMn) through Nrf2-regulated antioxidant defenses associated with MAPKs pathway using HeMn-HeKn co-culture.
2 To study the role of Nrf2 in regulation of UVA-induced MMP-1 in association with modulation of MAPKs pathway using siRNA knockdown of Nrf2 in human keratinocyte cells.
3 To evaluate antiphotoaging effects of promising natural products and sulforaphane on UVA-induced MMP-1 through Nrf2-regulated antioxidant defenses in mouse skin
