1.to develop a practical synthetic method for the construction of indolizidine' s ring having the hemiaminal moiety,
2.to apply such method for the synthesis of tyloindicine F and 8a-hydroxysepticine,
3.to verify their proposed structure,
4.to provide sufficient material for theirs pharmacological evaluation. In addition, we planned to identify the essential structural elements required for the cytotoxic activity, comparing to our previously synthesized tylophora analogues in hand.
